University of Minnesota
Institute for Engineering in Medicine
http://iem.umn.edu/
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OTTO SCHMITT DISTINGUISHED LECTURE SERIES



   John C. Gore, Ph.D.
   University Professor
   Hertha Ramsey Cress Chair in Medicine
   Professor of Radiology and Radiological Sciences
   Professor of Biomedical Engineering
   Professor of Molecular Physiology and Biophysics
   Profressor of Physics and Astronomy
   Director, Vanderbilt University Institute of Imaging
   Science (VUIIS)
   Tuesday, November 1, 2016
   Networking lunch to start at    11:30AM, followed by presentation    12:00PM - 1:00PM

   2-102 CMRR Seminar Room

“New developments in structural and functional MRI”

Abstract: Several new experimental observations promise to extend the role of MRI in neuroscience. For example, temporal diffusion spectroscopy uses measurements of apparent diffusion rates over different time scales to derive microstructural information such as axon sizes non-invasively. Also in white matter, anisotropic correlations between resting state MRI signals from adjacent voxels were recently reported. These correlations can be analyzed in similar manner as diffusion tensors (but without diffusion gradients) and often appear to follow white matter tracts and reveal an apparent underlying functional structure. The biophysical origins of these signals are under active investigation as they potentially provide new insights into information flow in white matter. Resting state correlations have also been discovered in the central grey matter of spinal cord, both in non-human primates and human subjects, and depict functional connectivity between sub-regions such as the ventral and dorsal horns. These correlations change after an injury and thus may provide a biomarker of the functional integrity of the cord. Aided by technical advances in ultra-high field imaging, these developments suggest potential new research directions and applications of MRI.



Biography

John C. Gore, Ph.D., holds the Hertha Ramsey Cress Chair in Medicine and is a University Professor of Radiology and Radiological Sciences, Biomedical Engineering, Physics and Astronomy, and Molecular Physiology and Biophysics at Vanderbilt University, where he also directs the Vanderbilt University Institute of Imaging Science. Dr. Gore obtained his Ph.D. in Physics at the University of London in the UK and also holds a degree in Law. He is a member of the National Academy of Engineering and an elected Fellow of the American Association for the Advancement of Science, the American Institute of Medical and Biological Engineering, the International Society for Magnetic Resonance in Medicine (ISMRM), the American Physical Society, the National Academy of Inventors and the Institute of Physics (UK). He is also a Distinguished Investigator of the Academy of Radiology Research. He is editor-in-chief of the journal Magnetic Resonance Imaging. He has been honored with several awards including the Gold Medal of the ISMRM (2004) for his contributions to the field of magnetic resonance imaging, the Earl Sutherland Award for Achievement in Research from Vanderbilt, and is an Honorary Professor at Zhejiang University in China. Dr. Gore founded the pioneering MRI research program at Hammersmith Hospital in the UK in the late 1970’s prior to establishing and directing the MRI research program at Yale University from 1982-2002. He has published over 600 original papers and contributions within the medical imaging field. His research interests include the development and application of multimodal imaging methods for understanding tissue physiology and structure, molecular imaging and functional brain imaging.